Korean J Gastrointest Endosc.  2007 Jan;34(1):9-13.

Expression of Mutant p53 Protein, p21(waf1/cip1) and Cyclin D1 in Dysplasia and Adenocarcinoma of Stomach

Affiliations
  • 1Department of Pathology, Wonkwang University School of Medicine, Iksan, Korea. kjyun@wonkwang.ac.kr
  • 2Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.

Abstract

BACKGROUND/AIMS: Gastric carcinoma is a major cause of morbidity and mortality in Korea. It evolves through dysplasia to an invasive adenocarcinoma. The carcinogenesis of dysplasia and adenocarcinoma in the stomach was investigated by examining the levels of mutant p53 protein, p21(waf1/cip1), and cyclin D1 expression in gastric dysplasia and invasive adenocarcinoma.
METHODS
Formalin- fixed paraffin-embedded tumors were examined immunohistochemically using the monoclonal antibodies to the 53 protein, p21(waf1/cip1) and cyclin D1.
RESULTS
Mutant p53 protein, p21(waf1/cip1) and cyclin D1 expression were found in 66.6% (12/18), 72.2% (13/18) and 33.8% (6/18) of dysplasia, and 45.0% (9/20), 15.0% (3/20) and 30.0% (6/20) of invasive adenocarcinoma, respectively.
CONCLUSIONS
These results suggest that p21(waf1/cip1), which is controlled by the p53 protein, plays a more important role in the carcinogenesis of the stomach than cyclin D1.

Keyword

p53 protein; p21(waf1/cip1); Cyclin D1; Stomach
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