Korean J Gastrointest Endosc.  2010 Dec;41(6):390-393.

The Solitary Polypoid Ganglioneuroma of the Ascending Colon

  • 1Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. jbi@med.yu.ac.kr
  • 2Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea.


Ganglioneuromas are neuroectodermal tumors composed of varying amount of ganglion cells, nerve fibers, supporting cells of the enteric nervous system. Ganglioneuromas of the GI tract are rare tumors. A 50-year-old man came to our hospital due to the mass of liver and adrenal gland which was examined with ultrasonography at local medical center. On admission, abdominal magnetic resonance imaging was taken and liver biopsy was done. The mass of liver was hyperplastic nodule. At colonoscopy, about 0.3~0.8 cm sized six polyps were noted. Except the 0.6 cm sized semipedunculated polyp of the ascending colon, the others were tubular adenomas. Histological examination of the polyp of the ascending colon revealed localized proliferation of nerve fibers and ganglion cells. These cells are positive for S-100 protein by immunihistochemistry. Therefore, he was diagnosed with polypoid ganglioneuroma of the ascending colon. We report this case because the solitary ganglioneuroma in large intestine without systemic disease was rare.


Ganglioneuroma; Large intestine; S-100 protein
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