Korean J Gastroenterol.  2000 Jan;35(1):103-110.

Biliary Bile Acid Analysis in the Patients with Bile Duct Cancer

Abstract

BACKGROUND/AIMS
Bile acids including deoxycholic acid (DCA) have been known as carcinogenic on human colonic mucosa. However, limited data on changes of bile acid composition in the patients with bile duct cancer are available. The aim of this study was to assess the changes in composition of biliary bile acids in patients with bile duct cancer. METHODS: The bile was collected from 35 patients with bile duct cancer (25 males, 10 females, mean age of 61.4 years) and 23 patients with bile duct stone for control (11 males, 12 females, mean age of 57.7 years) bile acid analysis was then performal by high performance liquid chromatography. RESULTS: The total bile acids concentration was not different between two groups. The concentrations of deoxycholic, glycodeoxycholic and taurodeoxycholic acid in the bile of cancer patients were higher than those in the bile of control group. However there was no statistical significance. The fractional ratio of taurocholic acid was higher in cancer patients than in control group (p=0.008). CONCLUSIONS: There was no statistically significant difference in DCA concentration between two groups. However, the fact that the DCA level was higher in the patients with bile duct cancer than in control group suggests the possibility of relationship between bile duct cancer and the changes in bile acid composition. Further study is needed to obtain more reliable results.

Keyword

Bile; Bile acid; Bile duct cancer

MeSH Terms

Bile Acids and Salts
Bile Duct Neoplasms*
Bile Ducts*
Bile*
Chromatography, Liquid
Colon
Deoxycholic Acid
Female
Humans
Male
Mucous Membrane
Taurocholic Acid
Taurodeoxycholic Acid
Bile Acids and Salts
Deoxycholic Acid
Taurocholic Acid
Taurodeoxycholic Acid
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