Korean J Fam Med.  2009 Jan;30(1):23-30. 10.4082/kjfm.2009.30.1.23.

Association of Serum Gamma Glutamyltransferase and Fasting Blood Glucose among Middle Aged and Elderly in Chuncheon: Hallym Aging Study

Affiliations
  • 1Department of Family Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
  • 2Department of Endocrinology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
  • 3Department of Cardiology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
  • 4Department of Social and Preventive Medicine, Hallym University College of Medicine, Chuncheon, Korea. dhkims@hallym.ac.kr
  • 5Hallym Research Institute of Clinical Epidemiology, Chuncheon, Korea.
  • 6Deptartment of Society, Human Development and Health, Harvard School of Public Health, Boston, USA.

Abstract

BACKGROUND: Serum gamma-glutamyltransferase (GGT) was reported to be associated with type 2 diabetes, various cardiovascular disease risk factors, and individual components of metabolic syndrome. We performed a cross-sectional study to elucidate the relations between GGT and impaired fasting glucose (IFG).
METHODS
The subject of this study included 693 adults (males 272, females 421) aged 45 years or over who have lived in Chuncheon, a suburban small-sized city. IFG was defined as elevated fasting plasma glucose (FPG) concentration of > or = 100 and < 126 mg/dl.
RESULTS
The risk of IFG appeared to increase with increasing levels of serum GGT even after adjusting for other covariates, such as body mass index and inflammatory markers among men only: adjusted odds ratios of IFG across GGT categories (< 25th, < 50th, < 75th and > or = 75th) were 1.0, 0.56, 1.57, and 2.79, respectively (P-value for trend 0.022). In women, the association between the risk of IFG and GGT was not statistically significant.
CONCLUSION
This study suggests that elevated level of GGT within the normal range is an independent predictor of impaired fasting glucose in middle-aged or older men but not in women.

Keyword

Gamma-Glutamyltransferase; Impaired Fasting Glucose; Insulin Resistance

MeSH Terms

Adult
Aged
Aging
Blood Glucose
Body Mass Index
Cardiovascular Diseases
Cross-Sectional Studies
Fasting
Female
gamma-Glutamyltransferase
Glucose
Humans
Insulin Resistance
Male
Middle Aged
Odds Ratio
Plasma
Reference Values
Risk Factors
Blood Glucose
Glucose
gamma-Glutamyltransferase
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