Korean J Epidemiol.  1998 Jun;20(1):60-69.

Cigarette Smoking, Alcohol Consumption, and Breast Cancer in Korea

Affiliations
  • 1Department of Preventive Medicine, Seoul National University College of Medicine, Korea.
  • 2Department of Surgery, Seoul National University College of Medicine, Korea.
  • 3Department of Surgery, Borame City Hostpital, Korea.

Abstract

A hospital-based case-control study was conducted to assess the relationship between cigarette smoking, alcohol consumption, and the risk of bgreast cancer in Korea. Histologically confirmed incident cases of breast cancer(n=146) were selected from the inpatients at the Department of Surgery, Seoul National University Hospital and Borame Hospital during 1994 to 1997. Women ithout self-reported past history of any malignandies were regarded as controls and selected at the same hospitals during the same period(n-153). Information on life-styles including cigarette smoking, alcohol drinking, and reproductive history were obtained by direct interview using standardixed questionnaire. Each case was matched with one control by 5-year age category(n=146). Adjusted odds ratios and 90% confidence intervals were estimated by unconditional linear logistic regression model. For smokers, age at first smoking was significantly associated with the breat cancer risk(adjusted OR=14.1, 90% CI=1.24-364.2). Particularly noteworthy was an increasing tendency of the breast cancer risk with the duration of alcohol consumtion in years aong alcohol drinkers(ptrend<0.1). These findings suggest that cigarette smoking at an earlier age and alcohol intake might contribute to the risk factor of breast cancer in Korean women. Further investigation on the association between genetic polymorphism of xenobiotic metabolism enxymes of environmental carcinogens and breast cancer should be needed.

Keyword

Breast neoplams; Cigarette smoking; Alcohol drinking

MeSH Terms

Alcohol Drinking*
Breast Neoplasms*
Breast*
Carcinogens, Environmental
Case-Control Studies
Female
Humans
Inpatients
Korea*
Logistic Models
Metabolism
Odds Ratio
Polymorphism, Genetic
Reproductive History
Risk Factors
Seoul
Smoke
Smoking*
Tobacco Products*
Surveys and Questionnaires
Carcinogens, Environmental
Smoke
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