Korean J Epidemiol.  2000 Jun;22(1):52-58.

Glutathione S-transferase(GST) M1 and T1 Genetic Polymorphism in Benign Breast Disorders of Korean Women

Affiliations
  • 1Department of Preventive Medicine, College of Medicine & Medical Research Institute, Dongguk University.
  • 2Department of Preventive Medicine, Dankuk University College of Medicine.
  • 3Department of Preventive Medicine, Seoul National University College of Medicine.

Abstract

PURPOSE: A hospital-based case-control study was conducted to evaluate the role of glutathione-S-transferase(GST)M1 and GSTT1 genetic polymorphism for developing benign breast disorders(fibrocystic diseases and fibroadenoma) in Korea. MATERIALS AND METHODS: Histologically confirmed incident cases of benign breast disorder(n=56) were selected from inpatients at the Department of General Surgery, Seoul National University Hospital since 1994. Women with free of self-reporting past history of any malignancies were regarded as controls who were selected from the inpatients at the same department at three hospitals during 1994 to 1998(n=180). Information on life-styles including reproductive factors were obtained by direct interview using questionnaire. Age and menopausal status were matched and 51 cases and 102 controls were finally selected. Odds ratio and 95% confidence interval were estimated by multiple logistic regression after adjusting for age, education, body mass index, smoking history, drinking history, menstrual regularity, age at menarch, age at first pregnancy, frequency of fullterm pregnancy, breast feeding history, duration of breast feeding, and family history of breast cancer. RESULTS: GSTM1-null type showed no significance related to the risk of benign breast disorder(adjusted OR=0.8, 95% CI=0.38-1.83) and GSTT1-null type was also not significant(adjusted OR=1.4, 95% CI=0.63-3.29). Increasing tendency of disease risk by the number of GSTs null type was not observed (ptrend>0.1) after adjusting for all other variables. DISCUSSIONS: Further investigation with larger sample size should be needed to provide more concrete information on the role of GST genetic polymorphism in benign breast cancer and a lots of studies relation in normal level of GST genetic polymorphism in general population should be performed.

Keyword

Benign breast disorders; Genetic polymorphism; GSTM1; GSTT1

MeSH Terms

Body Mass Index
Breast Feeding
Breast Neoplasms
Breast*
Case-Control Studies
Drinking
Education
Female
Glutathione*
Humans
Inpatients
Korea
Logistic Models
Odds Ratio
Polymorphism, Genetic*
Pregnancy
Sample Size
Seoul
Smoke
Smoking
Surveys and Questionnaires
Glutathione
Smoke
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