Korean J Dermatol.  2011 Feb;49(2):119-124.

Therapeutic Effect of 1% Pimecrolimus for the Treatment of Senile Purpura

Affiliations
  • 1Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. drchosh@hotmail.com
  • 2Department of Anesthesiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

BACKGROUND
Senile purpura is characterized by ecchymoses on the extensor surfaces of the forearms and the dorsa of hands in the elderly. The prevalence is around 10% in the eight and ninth decades. Its occurrence is secondary to the fragility of blood vessel walls caused by atrophy of dermal collagen bundles and solar elastosis due to intrinsic aging and photoaging. For prevention of senile purpura, sunscreens and barrier protection should be used. However, there has been no specific medical treatments developed for senile purpura.
OBJECTIVE
The purpose of this study was to evaluate the clinical efficacy of a topical calcineurin inhibitor for the treatment of senile purpura.
METHODS
Seven patients with senile purpura applied 1% pimecrolimus cream twice daily for 2 weeks. Efficacy was evaluated by the subject's assessment and by the objective findings using photographic assessment.
RESULTS
There was an 8.5% reduction in the purpuric area compared with the initial lesion. When the Wilcoxon signed-rank test was used for determination of the purpuric area between the pre-treatment condition and the post-treatment condition, the therapeutic effect was statistically significant (p=0.004). Three of seven patients (42.9%) were satisfied with their treatment, and four of them (57.1%) were neither satisfied nor dissatisfied. No adverse events were observed during the treatment and follow up periods.
CONCLUSION
This study shows that 1% pimecrolimus cream can be an effective and safe treatment modality for senile purpura.

Keyword

Calcineurin inhibitor; Pimecrolimus; Senile purpura

MeSH Terms

Aged
Aging
Atrophy
Blood Vessels
Calcineurin
Collagen
Ecchymosis
Follow-Up Studies
Forearm
Glycosaminoglycans
Hand
Humans
Prevalence
Purpura
Sunscreening Agents
Tacrolimus
Calcineurin
Collagen
Glycosaminoglycans
Sunscreening Agents
Tacrolimus
Full Text Links
  • KJD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error