Korean J Dermatol.  2005 Aug;43(8):1130-1132.

Wells' Syndrome Associated with Esophageal Squamous Cell Carcinoma

• Lee UH
• Choi JC
• Chun DK

Abstract

Wells' syndrome or eosinophilic cellulitis is a recurrent inflammatory dermatosis, characterized clinically by acute dermatitis resembling cellulitis. The histopathologic findings show diffuse dermal eosinophilic infiltration and characteristic `flame figures'. The etiology and pathogenesis are unknown, however, various associated disorders such as hematological diseases, infections, arthropod bites, drugs, and surgery have been documented. Wells' syndrome has previously been reported in only 4 cases of non-hematological malignancy. A 57-year-old man with esophageal squamous cell carcinoma developed recurrent, mildly tender, urticarial plaques on the trunk and left forearm. A skin biopsy specimen revealed histopathologic findings compatible to Wells' syndrome. Skin lesions resolved with systemic corticosteroids therapy without recurrence until now. We report a case of Wells' syndrome associated with esophageal squamous cell carcinoma

Keyword

Wells' syndrome; Esophageal squamous cell carcinoma

MeSH Terms

Adrenal Cortex Hormones
Arthropods
Biopsy
Carcinoma, Squamous Cell*
Cellulitis
Dermatitis
Eosinophils
Forearm
Hematologic Diseases
Humans
Middle Aged
Recurrence
Skin
Skin Diseases
Adrenal Cortex Hormones