Korean J Dermatol.  2012 Nov;50(11):994-997.

Ulcerative Necrobiosis Lipoidica Improved by Hydroxychloroquine

Affiliations
  • 1Department of Dermatology, Maryknoll Medical Center, Busan, Korea. sea7th@naver.com

Abstract

Necrobiosis lipoidica (NL) is a chronic granulomatous skin disease of unknown etiology, which can be seen in patients with diabetes mellitus. Typical lesions of NL appear on the pretibial skin as painful yellow-brown inflammatory plaques with raised borders and atrophic centers. Ulceration occurs in approximately 35% of cases, leading to increased risk of secondary bacterial infection and scarring. Although there have been many proposed therapies for ulcerative NL, the response to treatment is often met with limited success. Here, we report a case of a 19-year-old girl with ulcerative NL, which showed improvements with oral hydroxychloroquine, an antimalarial agent.

Keyword

Hydrochloroquine; Ulcerative necrobiosis lipoidica

MeSH Terms

Bacterial Infections
Cicatrix
Diabetes Mellitus
Humans
Hydroxychloroquine
Necrobiosis Lipoidica
Necrobiotic Disorders
Skin
Skin Diseases
Ulcer
Young Adult
Hydroxychloroquine
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