Korean J Dermatol.
2010 Aug;48(8):684-688.
Blastoid Mantle Cell Lymphoma: A Case Report
- Affiliations
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- 1Department of Dermatology, College of Medicine, Soonchunhyang Universiy, Cheonan, Korea. dermsung@schmc.ac.kr
- 2Department of Pathology, College of Medicine, Soonchunhyang Universiy, Cheonan, Korea.
Abstract
- Mantle cell lymphoma (MCL) is a low-grade malignant lymphoma derived from a subset of B-cells localized in the mantle zone of the lymphoid follicle. MCL commonly involves extranodal sites, usually as a manifestation of disseminated disease. The immunophenotype of MCL is characterized as CD20+, CD5+ and Cyclin D1+. Blastoid mantle cell lymphoma (BV-MCL) is a rare variant and has a more aggressive clinical course. In the blastoid variant, the genetic profile is often more complex and includes tetraploid chromosomes, CCND1 amplification, a higher incidence of p53 gene mutations, and p16(INK4a) deletions. We report a case of a 62-year-old male patient who presented with erythematous subcutaneous nodules on the lower back. He had been treated for BV-MCL of the testis which had occurred 1 year ago. The analysis of histopathological and immunohistochemical examinations of the skin lesions also revealed a BV-MCL.
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