Korean J Biol Psychiatry.  2015 May;22(2):87-94. 10.0000/kjbp.2015.22.2.87.

Electroencephalographic Characteristics of Alcohol Dependent Patients: 3-Dimensional Source Localization

Affiliations
  • 1Department of Psychiatry, College of Medicine, Chungbuk National University, Cheongju, Korea. cjshin@chungbuk.ac.kr
  • 2Yesarang Hospital, Cheongju, Korea.

Abstract


OBJECTIVES
The power spectral analysis of electroencephalogram has been widely used to reveal the pathophysiology of the alcoholic brain. However, the results were not consistent and the three dimensional study can be hardly found. The purpose of this study was to investigate characteristics of the three dimensional electroencephalographic (EEG) activity of alcohol dependent patients using standardized low resolution electromagnetic tomography (sLORETA).
METHODS
The participants consisted of 30 alcohol dependent patients and 30 normal healthy controls. All the participants were males who had refrained from alcohol at least one month and were not taking any medications. Thirty two channel EEG data was collected in the resting state with eyes-closed condition during 30 seconds. The three dimensional data was compared between two groups using sLORETA for delta, theta, alpha, beta1, beta2, and beta3 frequency bands.
RESULTS
sLORETA revealed significantly increased brain cortical activity in alpha, beta1, beta2, and beta3 bands each in alcohol dependent patients compared to normal controls. The voxels showing the maximum significance were in the left transverse temporal gyrus, left superior temporal gyrus, left anterior cingulate, and left fusiform gyrus in alpha, beta1, beta2, and beta3 bands respectively.
CONCLUSIONS
These results suggest that chronic alcohol intake may cause neurophysiological changes in cerebral activity. Therefore, the measuring of EEG can be helpful in understanding the pathophysiology of cognitive impairements in alcohol dependence.

Keyword

sLORETA; Alcohol dependence; Cortical activation; Current source analysis; Source localization; Functional neuroimaging

MeSH Terms

Alcoholics
Alcoholism
Brain
Electroencephalography
Functional Neuroimaging
Humans
Magnets
Male
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