Korean J Asthma Allergy Clin Immunol.  2006 Mar;26(1):46-51.

Eosinophilic Lung Disease : Clinical Features of 25 Patients

Abstract

BACkGROUND
Eosinophilic lung disease (ELD) or eosinophilic pneumonia is recognized as a heterogeneous group of disorders characterized by varying degrees of pulmonary parenchymal or blood eosinophilia. The spectrum of diseases that can be primarily or secondarily associated with pulmonary eosinophilia is diverse. We evaluated the clinical features of ELD in 25 patients. METHOD: Twenty-five patients diagnosed as ELD were evaluated. Data were obtained prospectively using the standard form of evaluation to find the cause of ELD. RESULT: The most common cause of ELD was a parasitic infection (n=7, 28%) and the others were idiopathic hypereosinophilic syndrome(n=6, 24%), Churg-Strauss syndrome (n=4, 16%), simple pulmonary eosinophilia (n=4, 16%), drug (n=2, 8%), and mycoplasma infection (n=2, 8%). At radiographic presentation, the ground-glass opacity was 45% (n=11), consolidation was 32% (n=8), and nodule was 24% (n=6). Mean peripheral blood eosinophil counts were 4,104.6+/-867.6/microliter. The mean serum total IgE levels measured by CAP were 3,309.0+/-688.9 kU/L in the parasite infection group. However, peripheral blood eosinophil counts or serum total IgE levels were not significantly different among the disease groups classified by causes of ELD. Organs with eosinophilic infiltration other than the lungs were the stomach (n=3), liver (n=3), skin (n=2), heart (n=1), and nerve (n=1).
CONCLUSION
Further and careful examinations are required to evaluate the causes of ELD. Moreover, we would like to stress the evaluation of curable causes, especially infectious disease such as parasite.


MeSH Terms

Churg-Strauss Syndrome
Communicable Diseases
Eosinophilia
Eosinophils*
Heart
Humans
Immunoglobulin E
Liver
Lung Diseases*
Lung*
Mycoplasma Infections
Parasites
Prospective Studies
Pulmonary Eosinophilia
Skin
Stomach
Immunoglobulin E
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