Korean J Asthma Allergy Clin Immunol.  2012 Sep;32(3):144-149.

Role of Prostaglandin D2 in the Pathogenesis of Asthma

Abstract

Prostaglandin D2 is a major lipid mediator released from activated mast cells of which metabolite 9alpha,11beta-prostaglandin F2 are used as a biomarker of mast cell activation in various type of asthma. Prostagladin D2 acts on DP1 (DP, PTGDR), CRTH2 (DP2) and TP receptors resulting in bronchoconstriction and airway eosinophilia and increase of Th2 cytokines. Several single nucleotide polymorphisms of DP and CRTH2 has been reported to be associated with asthma susceptibility in some population. Thus, prostaglandin D2 may play an important role for the pathogenesis of asthma. Therefore, prostaglandin D2 could be a potential new therapeutic target for asthma. Indeed, several CRTH2 antagonists are currently under investigation for the treatment for asthma. Here, this review will summarize the biosynthesis of prostaglandin D2 and its receptors and focus on the role of prostaglandin D2 in the pathogenesis of asthma including genetic association studies.

MeSH Terms

Asthma
Bronchoconstriction
Cytokines
Eosinophilia
Genetic Association Studies
Mast Cells
Polymorphism, Single Nucleotide
Prostaglandin D2
Receptors, Immunologic
Receptors, Prostaglandin
Receptors, Thromboxane
Cytokines
Prostaglandin D2
Receptors, Immunologic
Receptors, Prostaglandin
Receptors, Thromboxane