Korean J Asthma Allergy Clin Immunol.
2012 Dec;32(4):268-271.
A Case of Vitamin K1 Induced Allergic Dermititis
Abstract
- BACKGROUND
Vitamin K1 (phytonadione), a fat-soluble vitamin, has widely been used to correct bleeding tendency. Although delayed hypersensitivity to vitamin K in new borns is relatively well known, it has rarely been reported in adults. CASE HISTORY: A 39-year-old woman with thyroid cancer presented with eczematous erythema and severe itching sense with local heat on her right buttock that occurred after intramuscular injection of vitamin K1 7 days ago. She had received intramuscular injections of vitamin K1 to correct bleeding tendency before total thyroidectomy.
RESULTS
The pathologic findings of a skin biopsy specimen revealed vacuolar dermatitis with perivascular inflammatory cell infiltration. The skin lesion rapidly improved after administration of oral prednisolone (30 mg/day), a topical steroid, and an oral antihistamine for 5 days. After resolution of the primary lesion, a patch test with vitamin K1 was performed. The patient showed a positive reaction to vitamin K1 with an erythematous plaque with blistering at vitamin K1 injection site.
CONCLUSION
We report here in a case of vitamin K1-induced delayed hypersensitivity reaction confirmed by a patch test.
