Korean J Asthma Allergy Clin Immunol.  2012 Dec;32(4):203-206.

Long-Lived Plasma Cell

Abstract

Plasma cells are usually considered short-lived plasma cells. This view is changing because plasma cells can survive for a long time in bone marrow. Long-lived plasma cells may be important in allergy because of the persistence of immunoglobulin E in allergic animal models after immune suppression. Allergic therapies efficiently control allergic symptoms but do not provide a cure, especially in adults. Elimination of long-lived plasma cells that secrete specific immunoglobulin E may provide a cure in allergic patients. The purpose of this review is to describe the creation of long-lived plasma cells and their importance in allergic diseases.

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