Korean Diabetes J.  2009 Apr;33(2):143-154. 10.4093/kdj.2009.33.2.143.

Associations between ApoB/ApoA-I Ratios and Metabolic Syndrome and its Components in Patients with Type 2 Diabetes

• Kim JE
• Kim WY
• Lee YJ
• Park JE
• Choi YJ
• Huh KB
• Hwang JY

• KMID: 2298071
• DOI: http://doi.org/10.4093/kdj.2009.33.2.143

Abstract

BACKGROUND
The Apolipoprotein B/apolipoprotein A-I ratio (apoB/apoA-I) is a powerful clinical indicator of metabolic syndrome. However, few studies have searched for an association between ApoB/ApoA-I and metabolic syndrome in Korean patients with type 2 diabetes. We investigated the relation between ApoB/ApoA-I and the risk of metabolic syndrome and its components. METHODS: Subjects were 812 (424 males and 388 females) Korean patients who were being treated for type 2 diabetes at Huh's Diabetes Center in Seoul. The patients were classified into quartiles (lowest:Q1-highest:Q4) of ApoB/ApoA-I by gender. Anthropometric and hematological characteristics and dietary intake using a food frequency questionnaire were assessed. RESULTS: The prevalence of metabolic syndrome in our sample was 47.9% in males and 66.5% in females. The odds ratios (OR) for metabolic syndrome and for having its components were significantly increased from Q2 to Q4 quartiles of ApoB/ApoA-I in males (OR = 5.37; 95% CI = 2.98-9.65 and OR = 7.41; 95% CI = 4.04-13.6) and females (OR = 2.57; 95% CI = 1.28-5.15 and OR = 8.49; 95% CI = 4.28-16.8). These trends withstood adjustment for age, duration of type 2 diabetes, fasting blood glucose levels, and macronutrient intake both in males (OR = 5.24; 95% CI = 2.80-9.24 and OR = 7.98; 95% CI = 4.09-15.6) and in females (OR=4.41; 95% CI = 2.26-8.61 and OR = 8.29; 95% CI = 3.85-17.8). CONCLUSION: ApoB/ApoA-I appeared to be independently associated with risk of having metabolic syndrome and its components in Korean patients with type 2 diabetes after adjustment for putative risk factors including macronutrient intake, a particularly important lifestyle factor for patients with type 2 diabetes. A follow-up study of this population should evaluate the mechanisms underlying the relation between ApoB/ApoA-I and metabolic syndrome and its components.

Keyword

Apolipoprotein A-I; Apolipoprotein B; Metabolic syndrome X; Type 2 diabetes mellitus

MeSH Terms

Apolipoprotein A-I
Apolipoproteins
Blood Glucose
Diabetes Mellitus, Type 2
Fasting
Female
Humans
Life Style
Male
Metabolic Syndrome X
Odds Ratio
Prevalence
Risk Factors
Surveys and Questionnaires
Apolipoprotein A-I
Apolipoproteins
Blood Glucose

Figure

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  Fig. 1 Daily average macronutrient intakes of male (A) and female (B) subjects. Upper figures for energy intake and lower figures for carbohydrate, protein, and fat intakes. P-values indicate statistical differences among four quartile groups from one-way ANOVA test abValues with different alphabets are significantly different among the four quartile groups in same gender by Duncan's multiple range test: P < 0.05.

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