J Korean Acad Fam Med.  2006 Aug;27(8):645-651.

Relationship between Serum gamma-glutamyltransferase Level and Serum Ferritin Level in Healthy Adults

Affiliations
  • 1Department of Family Medicine, Yong-dong Severance Hospital, Yonsei University College of Medicine, Korea. faith@yumc.yonsei.ac.kr
  • 2Department of Laboratory Medicine, MizMedi Hospital, Seoul, Korea.

Abstract

BACKGROUND: Serum gamma-GT is one of the biliary enzymes with the only enzymatic activity capable of cleaving extracellular glutathione, thus originating precursor amino acids for the intracellular resynthesis of glutathione. Several population-based studies have shown a strong cross-sectional association between serum gamma-GT concentration and cardiovascular risk factors. And prospective studies showed that serum gamma-GT concentration had a prognostic impact on cardiovascular mortality. But, the mechanism by which gamma-GT is associated with cardiovascular disease is not elucidated. We hypothesized that there was an association between serum gamma-GT and ferritin, a marker of oxidative stress. In this study, we investigated the relationship between serum gamma-GT and serum ferritin.
METHODS
By reviewing the medical records of 288 healthy adults, we determined the serum levels of gamma-GT and ferritin according to age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, LDL-cholesterol, fasting blood sugar, hs-CRP, serum ferritin, AST, ALT, uric acid and smoking history. We studied the relationship between the variables by Pearson correlation coefficients and multiple stepwise regression analysis. Mean values of serum gamma-GT according to the smoking history were compared using t-test.
RESULTS
Serum gamma-GT correlated positively with serum ferritin (r=0.42; P<0.001). BMI, triglycerides, total cholesterol, fasting blood sugar, AST and ALT also showed statistically significant correlation. Smokers showed significantly higher serum gamma-GT. Serum gamma-GT correlated with serum ferritin, ALT, current smoking and triglycerides by multiple stepwise regression analysis.
CONCLUSION
Serum gamma-GT correlated positively with serum ferritin.

Keyword

gamma-GT; ferritin; oxidative stress

MeSH Terms

Adult*
Amino Acids
Blood Glucose
Blood Pressure
Body Mass Index
Cardiovascular Diseases
Cholesterol
Fasting
Ferritins*
gamma-Glutamyltransferase*
Glutathione
Humans
Medical Records
Mortality
Oxidative Stress
Risk Factors
Smoke
Smoking
Triglycerides
Uric Acid
Amino Acids
Blood Glucose
Cholesterol
Ferritins
Glutathione
Smoke
Triglycerides
Uric Acid
gamma-Glutamyltransferase
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