Korean J Urol.  2005 Aug;46(8):819-822.

Outcome of Microsurgical Multiple Testicular Sperm Extraction for Patients with Y Chromosome Microdeletion

• Kim WT
• Seo JT

Abstract

Purpose
Y chromosome microdeletions have been intimately associated with idiopathic male infertility, and the incidence of microdeletions has been reported to 15-20% in men with nonobstructive azoospermia (NOA). We analyzed azoospermic factor (AZF) deletions in NOA patients, and then compared the surgical outcomes after microsurgical multiple testicular sperm extraction (TESE), between patients with and without AZF deletions.
Materials and Methods
90 patients with NOA, who were investigated for microdeletion of Y chromosome, underwent microsurgical multiple TESE. The age, testicular size, endocrinological profile and outcome of sperm retrieval were compared between patients with and without AZF deletions.
Results
Y microdeletions were found in 6.7% (6/90). The sperm retrieval rates, without and with microdeletions were 23.8 (20/84) and 50% (3/6), respectively. There were no significant differences in the age, testicular size, endocrinological profile and sperm retrieval rates between the patients with microdeletion and without.
Conclusions
Y microdeletions do not affect the sperm retrieval rates of NOA patients.

Keyword

Y chromosome; Infertility

MeSH Terms

Azoospermia
Humans
Incidence
Infertility
Infertility, Male
Male
Sperm Retrieval
Spermatozoa*
Y Chromosome*