J Korean Acad Child Adolesc Psychiatry.  2008 Oct;19(3):147-155.

Efficacy and Tolerability of Osmotic Release Oral System-Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder According to Comorbid Psychiatric Disorders

Affiliations
  • 1Department of Psychiatry, Hallym University College of Medicine, Anyang, Korea. hongdr@chol.com
  • 2Department of Psychiatry, Pochon CHA University College of Medicine, Seongnam, Korea.
  • 3Department of Occupational and Environmental Medicine, Hallym University College of Medicine, Anyang, Korea.

Abstract


OBJECTIVES
The purpose of this study was to evaluate the efficacy and tolerability of osmotic release oral systemmethylphenidate (OROS-MPH) in children with attention-deficit hyperactivity disorder (ADHD) and comorbid psychiatric disorders.
METHODS
This was an 8-week open label study of OROS-MPH monotherapy. The subjects were 113 children with ADHD aged 6-12 years. Outcome measures were the Korean version of the parent ADHD Rating Scale (K-ARS), Korean version of the Conners Parent Rating Scale (K-CPRS), Clinical Global Impression-Severity and Clinical Global Impression-Improvement. Side effects were monitored using Barkley's Side Effect Rating Scale. We compared the change-over-time in the mean scores of the outcome measure according to the comorbidity of disruptive behavior disorder, depressive disorder, anxiety disorder, and tic disorder.
RESULTS
The mean K-ARS and K-CPRS scores were significantly decreased, regardless of the comorbidity. The mean doses of OROS-MPH and dropout rate did not differ significantly according to comorbidity. The OROS-MPH was well tolerated, regardless of the comorbidity. However, children with tic disorder reported a higher frequency of tics or nervous movements between the 2nd and 8th week than those without tic disorder.
CONCLUSION
The OROS-MPH is effective for decreasing the symptoms of ADHD, and it is well tolerated, even by patients with comorbid psychiatric disorders.

Keyword

ADHD; OROS-Methylphenidate; Comorbidity; Efficacy; Tolerability

MeSH Terms

Aged
Anxiety Disorders
Attention Deficit and Disruptive Behavior Disorders
Child
Comorbidity
Depressive Disorder
Humans
Outcome Assessment (Health Care)
Parents
Patient Dropouts
Tic Disorders
Tics
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