J Korean Acad Child Adolesc Psychiatry.
2011 Dec;22(4):253-261.
An Open-Label Study of the Improvements in Clinical Symptoms and Neurocognitive Functions in Korean Children and Adolescents with Attention-Deficit Hyperactivity Disorder after Treatment with Metadate CD
- Affiliations
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- 1Seoul Brain Research Institute, Seoul, Korea.
- 2Department of Psychiatry, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea.
- 3Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 4Department of Psychiatry, Kyung Hee University School of Medicine, Seoul, Korea.
- 5Department of Child & Adolescent Psychiatry, Severance Children's Hospital and Institute for Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 6Department of Psychiatry and Institute of Mental Health, Hanyang University College of Medicine, Seoul, Korea.
- 7Department of Neuropsychiatry, Chung-Ang University College of Medicine, Seoul, Korea. hawkeyelys@hanmail.net
Abstract
OBJECTIVES
This study aimed to investigate the efficacy and safety of Metadate CD (MCD) when given to Korean children and adolescents with attention-deficit hyperactivity disorder (ADHD). We also explored the effects of the drug on diverse neurocognitive functions.
METHODS
Ninety-one subjects with ADHD (mean age 8.6+/-2.2 years) were recruited at 6 outpatient clinics in Seoul, Korea. We used the ADHD Rating Scale (ARS), Clinical Global Impression (CGI), and comprehensive attention test (CAT) to measure the drug's effects.
RESULTS
After 0.92+/-0.32mg/kg/day of MCD were administered for 57.4+/-7.6 days, there was a 48.5% reduction in the mean total ARS scores (p<.001). Fifty-seven subjects (64.8%) showed either much improved or very much improved outcomes on the CGI-Improvement scale. The CGI-Severity scale also decreased from an average of 4.7 to an average of 2.9 (p<.001). Errors and response time standard deviations of the CAT, sustained attention test-to-response tasks, the flanker test, and divided attention test scores decreased after treatment (p<.05). The forward memory span of the spatial working memory test scores increased (p<.05). Thirty-five patients (39.8%) experienced side effects, of which the most common were headache (14.8%), nausea (12.5%), and anorexia (9.1%).
CONCLUSION
This open-label study suggests that MCD is effective and safe in improving the symptoms and neurocognitive functions of Korean children and adolescents with ADHD.
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