J Korean Acad Child Adolesc Psychiatry.  2013 Sep;24(3):157-163.

An Open-Label Study of OROS-Methylphenidate for Neuropsychological Changes in Children and Adolescents with Attention-Deficit Hyperactivity Disorder

  • 1Department of Psychiatry, Myongji Hospital, Goyang, Korea.
  • 2Yonsei Junior Clinic, Seongnam, Korea.
  • 3Department of Child and Adolescent Psychiatry, College of Medicine, Yonsei University, Seoul, Korea. dhsong@yuhs.ac
  • 4Institute of Behavioral Science in Medicine, College of Medicine, Yonsei University, Seoul, Korea.
  • 5Department of Psychiatry, Konyang University College of Medicine, Daejeon, Korea.


Previous studies reported that attention-deficit hyperactivity disorder (ADHD) resulted from a deficit of selective attention and sustained attention. In this study, we assessed the result of methylphenidate-induced changes of the cerebral frontal executive functions in patients with ADHD.
The subjects in this study consisted of 16 ADHD patients whose age ranged from 7 to 12. We used ADHD Diagnostic System (ADS) for the attention improvement, and the Stroop Test for the executive function response to pharmacotherapy with MPH.
After pharmacotherapy with methylphenidate for 12 weeks, the study group showed improvement in the clinical aspects through Clinical Global Impression-Severity, ADHD-rating scale and Inattention/Overactivity With Aggression Conner's Parents Rating Scale. In the ADS test, only in auditory task there was a decrease of both the response time and the standard deviation of the response time significantly. In the Stroop Test, there was a decrease in the word task, color task and color-word task significantly.
Our results show that psychostimulant medication improves neuropsychological function, including the cerebral frontal executive function. This study implies that we have to consider the improvement of executive function, as well as attention when evaluating the efficacy of treatment.


ADHD; Methylphenidate; Neuropsychological Change; Stroop Test
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