Korean J Psychopharmacol.  2014 Jan;25(1):11-20.

Adverse Effects and Pharmacological Management of Newer Antidepressants: Focusing on Common but Under-Recognized Adverse Effect

  • 1Department of Psychiatry, College of Medicine, Dankook University, Cheonan, Korea. kykylee2@gmail.com


Nowadays newer antidepressants are commonly used in clinical practice, since they are as effective as tricyclic antidepressant, but show less adverse effects. However there are many unexpected adverse effects of these drugs. It is one of the most common causes of treatment failure. I reviewed these adverse effects and pharmacological management focusing on common but under-recognized adverse effects of newer antidepressant. I reviewed newer antidepressant-induced sleep related movement disorder, sweating, tremor, abnormal bleeding. In this paper, newer antidepressants include selective serotonin reuptake inhibitor (fluoxetine, fluvoxamine, citalopram, escitalopram, sertraline, paroxetine), serotonin norepinephrine reuptake inhibitor (venlafaxine, duloxetine), norepinephrine and dopamine reuptake inhibitor (bupropion), noradrenergic and specific serotonergic antidepressant (mirtazapine), and reversible inhibitor of monoamine oxidase A (moclobemide). I suggest that psychiatrists should know not only well-recognized but also under-recognized common adverse effects and their pharmacological management of newer antidepressants, so that it will be helpful to treat patients with psychiatric illness using newer antidepressants and to make better outcome.


Newer antidepressant; Under-recognized adverse effect; Management
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