J Clin Neurol.  2005 Apr;1(1):8-13. 10.3988/jcn.2005.1.1.8.

Current Issues in Migraine Genetics

• Lee JY
• Kim M

• KMID: 2287710
• DOI: http://doi.org/10.3988/jcn.2005.1.1.8

Abstract

Migraine often runs in families and is associated with both genetic and environmental factors. Clinical and genetic heterogeneity as well as the influence of environmental factors have hampered the identification of the gene responsible for migraine disorder. Family/twin studies suggest the presence of hereditary susceptibility. Several different types of mutations or association studies with genetic polymorphism in neurotransmitters, inflammatory cytokines, homocysteine metabolism, mitochondria, or other risk genes in cerebrovascular disorders have been reported. Recently, progress of molecular genetics in familial hemiplegic migraine has provided important insights, a channelopathy, and now extending to a growing list of membrane excitability disorders. Further identification of candidate genes for migraine and exploring the correlation between phenotype and genotype are expected in the future for the understanding of migraine pathophysiology.

Keyword

Migraine; Genetics

MeSH Terms

Cerebrovascular Disorders
Channelopathies
Cytokines
Genetic Heterogeneity
Genetics*
Genotype
Homocysteine
Humans
Membranes
Metabolism
Migraine Disorders*
Migraine with Aura
Mitochondria
Molecular Biology
Neurotransmitter Agents
Phenotype
Polymorphism, Genetic
Cytokines
Homocysteine
Neurotransmitter Agents

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