Korean J Psychopharmacol.  2012 Oct;23(4):190-199.

The Effect of Weight Reduction on the Obesity-Related Quality of Life, Physical and Emotional Well-Being in Obese Schizophrenic Inpatients

  • 1Department of Psychiatry, Naju National Hospital, Naju, Korea. yoonbh@chollian.net


The purpose of this study was to assess the effect of the weight reduction program designed for schizophrenic patients. It's effects were assessed especially in the aspects of the obesity-related quality of life, emotional and physical well-being of the patients.
Fifty-one obese schizophrenic inpatients were enrolled in a 12-week, randomized weight reduction program. Thirty-two patients were randomly assigned to an intervention group in which they received the weight management program. Nineteen patients were allocated to the control group in which they received the usual clinical inpatient treatments. Body weight, Body Mass Index (BMI) and Quality of Life Scales such as Short Form of Medical Outcome Study (SF-36), Korean version of Obesity-related Quality of Life Scale (KOQOL) and Korean version of Body Weight, Image and Self-Esteem Evaluation Questionnaire (B-WISE-K) were evaluated during 12-week period. All assessments were done at baseline, 4, 8 and 12 week. Repeated measures of analysis of variance and post-hoc comparisons were done to compare the group differences from baseline at each visit.
Sixteen of 32 (50%) patients in intervention group and 12 of 19 (69.4%) patients in control group completed this study. We found significant group by time interaction effects in weight, BMI and waist circumferences (p<0.05, respectively). The weight changes from baseline to 8 week and 12 week were significant in post-hoc comparisons between intervention and control groups (p<0.05 and p<0.01, respectively). The changes of BMI and waist circumference from baseline to 12-week were also significant in post-hoc comparisons (p<0.05). After completion of the weight management program, there were significant differences on the subjective estimates such as physical component summary of SF-36, and total scores, psychosocial heath, physical health and diet of the KOQOL, and total scores of B-WISE-K between intervention and control group. These significant differences were found at 12-week of treatment in post-hoc comparisons (p<0.05, respectively).
The weight reduction program was effective for weight loss in schizophrenic inpatients. In addition, it might improve the subjective estimates such as obesity-related quality of life and weight-related body image in schizophrenic inpatients.


Schizophrenia; Obesity; Weight reduction; Obesity-related quality of life; Well-being

MeSH Terms

Body Image
Body Mass Index
Body Weight
Outcome Assessment (Health Care)
Quality of Life
Surveys and Questionnaires
Waist Circumference
Weight Loss
Weight Reduction Programs
Weights and Measures
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