Korean J Psychopharmacol.
2004 Dec;15(4):485-487.
Acute Pancreatitis Associated with Olanzapine: A Case Report
- Affiliations
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- 1Department of Psychiatry, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. cykim@amc.seoul.kr
Abstract
- Olanzapine is a thienobenzodiazepine similar in structure to clozapine. Several case reports have suggested that clozapine and olanzapine may be associated with the induction of acute pancreatitis. We present a case of acute pancreatitis in 39-year-old male patient with schizophrenia who had been taking 10 mg of olanzapine daily for 3 years. He had no known risk factors for the development of acute pancreatitis. He experienced second and third attacks of acute pancreatitis within 2 months of being under olanzapine. After undergoing an endoscopic procedure and stopping taking olanzapine, pancreatitis has not been relapsed for 3 months. Atypical antipsychotics such as olanzapine may be associated with the induction of pancreatitis therefore, it is necessary to pay close attention to its occurrence and mechanism.
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