J Breast Cancer.  2008 Dec;11(4):172-179. 10.4048/jbc.2008.11.4.172.

Expression of Cyclin D1 and bcl-2 in Infiltrative Ductal Carcinoma of the Breast: Their Correlations and Clinical implications

• Hong YK
• Baik SS
• Chung MS
• Yoon HS

• KMID: 2286582
• DOI: http://doi.org/10.4048/jbc.2008.11.4.172

Abstract

PURPOSE: Cyclin D1 and bcl-2 are involved in cell proliferation and apoptosis in tumor development and are commonly expressed in breast cancer. But there are few clinical reports on the correlation between cyclin D1 and bcl-2 expression. This study was designed to analyze the correlations of cyclin D1 and bcl-2 and their clinical implications in breast cancer.
METHODS
Immunohistochemical expression of cyclin D1 and bcl-2 were studied in 342 infiltrative ductal carcinoma cases and were compared with clinicopathologic parameters such as age, tumor size, histologic grade, lymph node status, p53, c-erbB2 and hormone receptors.
RESULTS
Cyclin D1 expression was found in 86 of 342 cases (25.1%). Bcl-2 was positive in 227 of 342 cases (66.4%). Bcl-2 overexpression was associated with the high expression of cyclin D1 (p=0.001). Correlation was detected between both cyclin D1 and bcl-2 and hormone receptor positivity (p<0.001). There was a reverse correlation between bcl-2 and histologic grade, p53, c-erbB2. And the bcl-2 overexpression group showed better disease free survival rates at 3-year follow up.
CONCLUSION
Higher expression of cyclin D1 was associated with bcl-2 overexpression. Positive estrogen receptor expression was associated with high cyclin D1 and bcl-2 expression. Bcl-2 tends to correlate with a positive clinical outcome.

Keyword

Bcl-2; Breast cancer; Cyclin D1; Prognosis

MeSH Terms

Apoptosis
Breast Neoplasms
Carcinoma, Ductal
Cell Proliferation
Cyclin D1
Cyclins
Disease-Free Survival
Estrogens
Follow-Up Studies
Lymph Nodes
Prognosis
Cyclin D1
Cyclins
Estrogens