J Breast Cancer.  2012 Mar;15(1):79-86. 10.4048/jbc.2012.15.1.79.

Prognostic Significance of High Expression of ER-beta in Surgically Treated ER-Positive Breast Cancer Following Endocrine Therapy

Affiliations
  • 1Department of Hospital Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea. klee@catholic.ac.kr
  • 2Department of Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea.
  • 3Department of Preventive Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.

Abstract

PURPOSE
This study evaluated estrogen receptor (ER)-beta mRNA and ER-beta protein expression and its prognostic implications in hormone receptor-positive breast cancer.
METHODS
Paraffin sections from 139 hormone receptor-positive breast cancer cases were prepared. The expression of ER-beta mRNA and protein were analyzed by branched-chain assay and immunohistochemistry (IHC), respectively.
RESULTS
The Allred score of ER-beta IHC was correlated with smaller tumor size (p=0.043), the Allred score of ER-alpha IHC (p<0.001), and the Allred score of progesterone receptor (PR) IHC (p=0.022) but not with the HER2 IHC score. ER-beta mRNA level was correlated with PR mRNA levels (p<0.001) but not with the Allred score of ER-beta IHC, ER-alpha IHC, and PR IHC, nor with the HER2 IHC score and ER-alpha mRNA level. In survival analysis, high expression of ER-beta mRNA was associated with worse disease-free survival along with poor differentiation, lymph node metastasis and absence of PR protein expression in univariate analysis (p=0.040, p=0.002, p=0.018, and p=0.007, respectively) and multivariate analysis (p=0.044, p=0.002, p=0.035, and p=0.007, respectively).
CONCLUSION
High expression of ER-beta mRNA is an independent predictor of disease recurrence in hormone-receptor-positive breast cancer.

Keyword

Breast neoplasms; Estrogen receptor; mRNA; Prognosis; Recurrence

MeSH Terms

Breast
Breast Neoplasms
Disease-Free Survival
Estrogens
Immunohistochemistry
Lymph Nodes
Multivariate Analysis
Neoplasm Metastasis
Paraffin
Prognosis
Receptors, Progesterone
Recurrence
RNA, Messenger
Estrogens
Paraffin
RNA, Messenger
Receptors, Progesterone
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