J Asthma Allergy Clin Immunol.  2001 Dec;21(6):1206-1210.

A case of Sulfone syndrome hypersensitivity associated with dapsone

Affiliations
  • 1Department of Internal Medicine, Sun General Hospital, Dae-Jeon, Korea. djna@sunhospital.com
  • 2Department of Clinical Pathology, Sun General Hospital, Dae-Jeon, Korea.

Abstract

Sulfone hypersensitivity syndrome, which is characterized by fever, skin rash, hemolytic anemia, atypical lymphocytosis, and acute hepatic injury, is a potentially fatal variant of dapsone hypersensitivity. A 62-year-old woman with a history of arthralgia developed sulfone syndrome while receiving dapsone 100 mg/day for 20 days. Fever, malaise, prominent rashes, hepatitis, eosinophilia and hemolytic anemia developed and she which required hospitalization. The patient's symptoms reversed following discontinuation of dapsone and administration of steroid (0.5 mg/kg). A case of sulfone syndrome and a brief review of the literature were presented.

Keyword

Sulfone syndrome; Dapsone; Hypersensitivity syndrome

MeSH Terms

Anemia, Hemolytic
Arthralgia
Dapsone*
Eosinophilia
Exanthema
Female
Fever
Hepatitis
Hospitalization
Humans
Hypersensitivity*
Lymphocytosis
Middle Aged
Dapsone
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