Korean J Physiol Pharmacol.  2015 Jul;19(4):335-340. 10.4196/kjpp.2015.19.4.335.

Zerumbone, Sesquiterpene Photochemical from Ginger, Inhibits Angiogenesis

  • 1Department of Biomedical Science, Catholic University of Daegu, Gyeongsan 712-702, Korea. toto0818@cu.ac.kr


Here, we investigated the role of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on angiogenesis using human umbilical vein endothelial cells (HUVECs). Zerumbone inhibited HUVECs proliferation, migration and tubule formation, as well as angiogenic activity by rat aorta explants. In particular, zerumbone inhibited phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis. In vivo matrigel plug assay in mice demonstrated significant decrease in vascularization and hemoglobin content in the plugs from zerumbone-treated mice, compared with control mice. Overall, these results suggest that zerumbone inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects.


Angiogenesis; Zerumbone; Vascular endothelial growth factor receptor; Human umbilical vein endothelial cells
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