Korean J Physiol Pharmacol.
1997 Jun;1(3):337-343.
Inhibitory effects of reversible proton pump inhibitors YH 1238 and YH1885 on acid secretion in isolated gastric cells
- Affiliations
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- 1Department of Pharmacology, Yonsei University, College of Medicine , Seoul South Korea.
- 2Yuhan Research Center, Yuhan Corporation.
Abstract
- Antiulcer effects of YH1238 and YH1885 were determined in the isolated gastric cells from human and rabbit stomach. Intracellular accumulation of (14C)-aminopyrine and (14C)-glucose oxidation were used as indicators of acid secretory ability of the gastric cells. Unstimulated and stimulated gastric cells with dibutyryl cAMP (10(-3) M) were used and the inhibitory effects of YH1238 and YH1885 on acid secretion were compared with known proton pump inhibitors such as omeprazole and SK&F 96067. Dibutyryl cAMP stimulated the (14C)-aminopyrine accumulation and (14C)-glucose oxidation, which were inhibited by YH1238, YH1885, SK&F 96067 and omeprazole. Inhibitory effects of YH1238, YH1885 and omeprazole on (14C)-aminopyrine accumulation in stimulated gastric cells were more potent than that of SK&F 96067 at the concentration of 10(-5) M. It is suggested that the reversible proton pump inhibitors YH1238 and YH1885 would be effective antiulcer agents.
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