Intest Res.  2009 Dec;7(2):123-128.

A Case of Gastrointestinal Amyloidosis in Asymptomatic Multiple Myeloma

Affiliations
  • 1Department of Internal Medicine, Eulji University College of Medicine, Eulji University Hospital, Daejeon, Korea. yjlee@eulji.ac.kr
  • 2Department of Pathology, Eulji University College of Medicine, Eulji University Hospital, Daejeon, Korea.

Abstract

Amyloidosis is a disorder characterized by extracellular deposition of amyloid materials in multiple organs and tissues. Amyloidosis commonly shows a systemic involvement. Gastrointestinal involvement is common in amyloidosis and is usually asymptomatic. The gastrointestinal manifestations include gastroparesis, diarrhea, steatorrhea, constipation, intestinal pseudo-obstruction, and bleeding. The diagnosis of amyloidosis is difficult because there are absence of systemic symptoms and nonspecific endoscopic findings. Asymptomatic multiple myeloma is an asymptomatic plasma-cell proliferative disorder associated with a high risk of progression to symptomatic multiple myeloma or amyloidosis. Recently, we experienced a 60-year-old man who presented with hematochezia and weight loss as manifestations of gastrointestinal amyloidosis involving the stomach and the colon induced in asymptomatic multiple myeloma confirmed by endoscopic biopsies and bone marrow biopsy. We report a case with a review of the literature.

Keyword

Amyloidosis; Multiple Myeloma; Stomach; Colon
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