Intest Res.  2011 Dec;9(3):238-242. 10.5217/ir.2011.9.3.238.

A Case of Cronkhite-Canada Syndrome Presenting with Hematochezia

Affiliations
  • 1Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ytjeen@korea.ac.kr

Abstract

Cronkhite-Canada syndrome (CCS) is a rare, non-familial hamartomatous polyposis syndrome characterized by multiple polyps in the entire gastrointestinal tract, nail dystrophy, skin pigmentation, and systemic alopecia. The clinical symptoms of this syndrome include diarrhea, abdominal pain, and alopecia often accompanied by taste disturbances, hypoalbuminemia, recurrent infections, nutritional absorption disturbances, heart failure, and gastrointestinal bleeding. We report a patient with CCS who was admitted complaining of hematochezia, melena, and a 1 month history of diarrhea, nail changes, taste disturbances, and alopecia. Upper endoscopy, colonoscopy, and capsule endoscopy were performed and showed numerous polyps in the stomach, small intestine, and large intestine. Histological sections of these polyps showed edematous stroma and cystically dilated foveolar epithelium, which was consistent with CCS. We diagnosed CCS based on the clinical symptoms and the histological findings of the polyps found via endoscopy. We report on this case and review this syndrome.

Keyword

Intestinal Polyposis; Capsule Endoscopy; Gastrointestinal Hemorrhage; Melena

MeSH Terms

Abdominal Pain
Absorption
Alopecia
Capsule Endoscopy
Colonoscopy
Diarrhea
Endoscopy
Epithelium
Gastrointestinal Hemorrhage
Gastrointestinal Tract
Heart Failure
Hemorrhage
Humans
Hypoalbuminemia
Intestinal Polyposis
Intestine, Large
Intestine, Small
Melena
Nails
Polyps
Skin Pigmentation
Stomach
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