Genomics Inform.
2010 Sep;8(3):159-163.
Comparison of Erythrocyte Traits Among European, Japanese and Korean
- Affiliations
-
- 1Department of Bioinformatics and Life Science, Soongsil University, Seoul 156-743, Korea. sskimb@ssu.ac.kr
Abstract
- Erythrocyte traits are heritable and indirect indicators of blood diseases caused by erythrocyte, but their genetic factors are largely unknown. So we performed genome-wide association study in 8,842 Korean individuals to identify genetic factors influencing erythrocyte traits. We identified 40 associations for three erythrocyte traits at genome-wide significance levels (p<1x10-6). We compared these associated loci with those reported in genome-wide association studies of European and Japanese. Our findings include previously identified loci (HBS1L-MYB, TMPRSS6, USP49 and CCND3) in other studies and novel associations (MRDS1/OFCC1, CSDE1, NRAS and 8 other loci). For example, SNP rs4895440 of HBS1L-MYB intergenic region on chromosome 6q23.3 is one of the most associations influencing erythrocyte traits (p=8.33x10-27).
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Dental anthropological study on the occlusal characteristics of the Koreans
- Validation and genetic heritability estimation of known type 2 diabetes related variants in the Korean population
- Gene Set Analyses of Genome-Wide Association Studies on 49 Quantitative Traits Measured in a Single Genetic Epidemiology Dataset
- Trends and Directions in Personality Genetic Studies
- No Association between the Polymorphism rs6943555 in the AUTS2 Gene and Personality Traits in Japanese University Students
