Genomics Inform.  2010 Sep;8(3):159-163.

Comparison of Erythrocyte Traits Among European, Japanese and Korean

Affiliations
  • 1Department of Bioinformatics and Life Science, Soongsil University, Seoul 156-743, Korea. sskimb@ssu.ac.kr

Abstract

Erythrocyte traits are heritable and indirect indicators of blood diseases caused by erythrocyte, but their genetic factors are largely unknown. So we performed genome-wide association study in 8,842 Korean individuals to identify genetic factors influencing erythrocyte traits. We identified 40 associations for three erythrocyte traits at genome-wide significance levels (p<1x10-6). We compared these associated loci with those reported in genome-wide association studies of European and Japanese. Our findings include previously identified loci (HBS1L-MYB, TMPRSS6, USP49 and CCND3) in other studies and novel associations (MRDS1/OFCC1, CSDE1, NRAS and 8 other loci). For example, SNP rs4895440 of HBS1L-MYB intergenic region on chromosome 6q23.3 is one of the most associations influencing erythrocyte traits (p=8.33x10-27).

Keyword

erythrocyte; GWAS; hematocrit; hemoglobin; red blood cell

MeSH Terms

Asian Continental Ancestry Group
DNA, Intergenic
Erythrocytes
Genome-Wide Association Study
Hematocrit
Hematologic Diseases
Hemoglobins
Humans
DNA, Intergenic
Hemoglobins
Full Text Links
  • GNI
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr