Gut Liver.  2012 Apr;6(2):223-228.

Polymorphisms of the Serotonin Transporter Gene and G-Protein beta3 Subunit Gene in Korean Children with Irritable Bowel Syndrome and Functional Dyspepsia

• Park CS
• Uhm JH

Abstract

BACKGROUND/AIMS
Many candidate gene studies have revealed that polymorphisms of the 5'-flanking controlled SERT gene linked polymorphic region (5HTT-LPR) gene and G-protein beta3 C825T gene might be associated with functional dyspepsia (FD) and irritable bowel syndrome (IBS). This study was performed to investigate polymorphisms of the 5HTT-LPR gene and G-protein beta3 C825T gene in FD and IBS in Korean children.
METHODS
In total, 102 patients with FD, 72 patients with IBS based on the Rome III criteria and 148 healthy controls without gastrointestinal symptoms were included in the study to analyze 5HTT-LPR and G-protein beta3 C825T polymorphisms.
RESULTS
5HTT-LPR genotype analysis revealed no signifi cant differences in FD and IBS patients compared with controls. The GNbeta3 C825T genotype distribution for CC, CT, and TT was 23.6%, 53.4%, and 23.0% in controls, 36.3%, 38.2%, and 25.5% in FD and 37.5%, 38.9%, and 23.6% in IBS, respectively. The CC genotype was more common in FD and IBS patients than controls (p<0.05). When the IBS patients were grouped according to IBS subtypes, CC genotype GNbeta3 C825T was common in diarrhea-dominant IBS, and the TT genotype was common in constipation-dominant IBS (p<0.05).
CONCLUSIONS
The CC genotype of G-protein beta3 C825T may be associated with FD and diarrhea-predominant IBS. The TT genotype may be associated with constipation-predominant IBS.

Keyword

Functional dyspepsia; Irritable bowel syndrome; Serotonin transporter; G-protein; Genotype

MeSH Terms

Child
Dyspepsia
Genotype
GTP-Binding Proteins
Heterotrimeric GTP-Binding Proteins
Humans
Irritable Bowel Syndrome
Rome
Serotonin
Serotonin Plasma Membrane Transport Proteins
GTP-Binding Proteins
Heterotrimeric GTP-Binding Proteins
Serotonin
Serotonin Plasma Membrane Transport Proteins