Gut Liver.
2011 Dec;5(4):437-446.
Effect of Helicobacter pylori Eradication on the Development of Reflux Esophagitis and Gastroesophageal Reflux Symptoms: A Nationwide Multi-Center Prospective Study
- Affiliations
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- 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
- 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. hyunchae@plaza.snu.ac.kr
- 3Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
- 4Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 5Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
- 6Department of Internal Medicine, Wonkwang University, Iksan, Korea.
- 7Department of Internal Medicine, Chonbuk National University School of Medicine, Jeonju, Korea.
- 8Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.
- 9Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
- 10Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
- 11Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
- 12Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.
- 13School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Korea.
Abstract
- BACKGROUND/AIMS
A two-year, prospective, nationwide multicenter study was undertaken to evaluate the effect of Helicobacter pylori eradication on the development of reflux esophagitis (RE) and gastroesophageal reflux disease (GERD) symptoms in the Korean population.
METHODS
In total, 1,489 subjects without RE were enrolled at the outpatient clinics of 12 tertiary hospitals nationwide, and 452 subjects underwent follow-up (F/U) for 2 years to evaluate the development of RE and GERD symptoms.
RESULTS
RE was found in 33 subjects (7.3% of 452 subjects) and 14 subjects (7.3% of 192 subjects) during the first and second year of F/U, respectively. H. pylori status was not associated with the development of RE. RE was found in six (9.0%) of 67 H. pylori-negative patients, in 26 (11.2%) of 233 eradicated subjects and in eight (7.0%) of 114 noneradicated subjects (p=0.532). Multivariate analysis showed that age > or =60 years (odds ratio [OR], 7.11; 95% confidence interval [CI], 1.92 to 26.41), alcohol consumption (OR, 4.43; 95% CI, 1.03 to 19.19) and F/U cholesterol levels > or =200 mg/dL (OR, 5.03; 95% CI, 1.32 to 19.17) were significant risk factors for the development of RE. There was no significant difference in the development of GERD symptoms or weight according to H. pylori status during the 2-year F/U.
CONCLUSIONS
Eradication of H. pylori did not affect the development of reflux esophagitis or GERD symptoms among patients in outpatient gastroenterology clinics in South Korea.
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