Gut Liver.  2011 Dec;5(4):432-436.

Increased Prevalence of Colorectal Neoplasia in Korean Patients with Sporadic Duodenal Adenomas: A Case-Control Study

• Chung WC
• Lee BI
• Roh SY
• Kwak JW
• Hwang SM
• Ko YH
• Oh JH
• Cho H
• Chae HS
• Cho YS

Abstract

BACKGROUND/AIMS
Recent data from Western populations have suggested that patients with sporadic duodenal adenomas are at a higher risk for the development of colorectal neoplasia. In this study, we compared the frequency of colorectal neoplasia in patients with sporadic duodenal adenomas to healthy control subjects.
METHODS
This retrospective case-control study used the databases of 3 teaching hospitals in Gyeonggi-do Province, South Korea. The colonoscopy findings of patients with sporadic duodenal adenomas were compared with those of age- and gender-matched healthy individuals who had undergone gastroduodenoscopies and colonoscopies during general screening examinations.
RESULTS
Between 2001 and 2008, 45 patients were diagnosed endoscopically with sporadic duodenal adenomas; 26 (58%) of these patients received colonoscopies. Colorectal neoplasia (42% vs 21%; odds ratio [OR], 2.8; 95% confidence interval [CI], 1.1 to 7.4) and advanced colorectal adenoma (19% vs 3%; OR, 9.0; 95% CI, 1.6 to 50.0) were significantly more common in patients with sporadic duodenal adenomas than in healthy control subjects.
CONCLUSIONS
Compared with healthy individuals, patients with sporadic duodenal adenomas were at a significantly higher risk for developing colorectal neoplasia. Such at-risk patients should undergo routine screening colonoscopies.

Keyword

Duodenal neoplasms; Colorectal neoplasms; Colonoscopy; Endoscopy

MeSH Terms

Adenoma
Case-Control Studies
Colonoscopy
Colorectal Neoplasms
Duodenal Neoplasms
Endoscopy
Hospitals, Teaching
Humans
Mass Screening
Odds Ratio
Prevalence
Republic of Korea
Retrospective Studies