Korean J Prev Med.  1990 Jun;23(2):194-200.

A Study on the Distributions of Paraoxonase Activity and the Factors affecting Paraoxonase Activity of a Rural opulation

Affiliations
  • 1Department of Preventive Medicine, College of Medicine, Hanyang University, Korea.

Abstract

The paraoxonase (E. C. 3.1.1.2.) is a major enzyme to detoxicate the organophosphorus and carbamate which are the most widely used as the agricultural spraying insecticides. To investigate the distributions of plasma paraoxonase activity and the fators affecting the enzyme activity, the plasmas of 945 Korean rural population were analyzed with the modified Krisch's direct sphectro;hotometry method. Three indices of the enzyme activity-basal activity, stimulated activity (by NaCl), % stimulation -were obtained from the analysis. Three indicies suggested unimodal distributions, so we couldn't identify the low activity group; risk group to organophosphorus & carbamate insecticides poisoning. There is no significant relation between 3 activity and the stimulated activity have significant relationship and high coefficient of determination with the activities of their parents (r2=0.30, 0.24; p<0.05), but the % stimulation does not (r2=0.02; p<0.05). These results suggest that the activity of paraoxonase is determined mainly by the genetic factor.

Keyword

paraoxonase activity; organophosphorus; carbamate; unimodal distrbution

MeSH Terms

Aryldialkylphosphatase*
Humans
Insecticides
Parents
Plasma
Poisoning
Rural Population
Aryldialkylphosphatase
Insecticides
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