Korean J Perinatol.  2015 Sep;26(3):174-182. 10.14734/kjp.2015.26.3.174.

The Association between Vitamin D Deficiency and Perinatal Outcomes of Pregnancy

Affiliations
  • 1Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea. md_cho@hanmail.net

Abstract

Vitamin D deficiency is a global health problem that increases risk for metabolic bone diseases in children and adults as well as many chronic illnesses including autoimmune diseases, type 2 diabetes, cardiovascular disease, infectious disease, and cancer. This has raised important questions concerning the physiological and clinical impact of low vitamin D levels during pregnancy, with implications for functions of vitamin D. The review describes the pathways that are required for metabolism and function of vitamin D, the various clinical complications that have been linked to impaired vitamin D status during pregnancy, and effects of vitamin D supplementation on maternal and neonatal outcomes.

Keyword

Vitamin D deficiency; Preeclampsia; Gestational diabetes; Perinatal outcome; Vitamin D supplementation

MeSH Terms

Adult
Autoimmune Diseases
Bone Diseases, Metabolic
Cardiovascular Diseases
Child
Chronic Disease
Communicable Diseases
Diabetes, Gestational
Female
Humans
Metabolism
Pre-Eclampsia
Pregnancy*
Vitamin D Deficiency*
Vitamin D*
Vitamins*
Vitamin D
Vitamins
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