Korean J Perinatol.  2011 Sep;22(3):221-228.

Prognosis of Extremely Low Birth Weight infants (1,000 g) Associated with Antenatal Magnesium Sulfate (MgSO4) Exposure

Affiliations
  • 1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea. yschang@skku.edu

Abstract


OBJECTIVE
To determine whether magnesium sulfate exposure is associated with a reduced risk of perinatal complications in extremely low birth weight infants (ELBWIs).
METHODS
Total 351 inborn extremely low birth weight infants admitted between January 2000 and December 2008 to Samsung Medical Center were divided into the prenatal MgSO4-exposed group (n=76), and control group (n=275), and were retrospectively analyzed. Multiple demographic, clinical characteristics and neonatal complications were compared.
RESULTS
Prenatally MgSO4-exposed ELBWIs had significantly higher gestational age, birth weight, and incidence of small for gestational age. In neonatal complications, retinopathy of premature (ROP) treated with laser was less common in MgSO4-exposed group. There were no differences between two groups in the incidence of respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), patent ductus arteriosus (PDA), PDA ligation, intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL), necrotizing enterocolitis (NEC), and mortality.
CONCLUSION
Perinatal exposure to magnesium sulfate was associated with decreased incidence of ROP treated with laser.

Keyword

Extremely low birth weight infants; Magnesium; Retinopathy of premature

MeSH Terms

Birth Weight
Bronchopulmonary Dysplasia
Diterpenes
Ductus Arteriosus, Patent
Enterocolitis, Necrotizing
Gestational Age
Hemorrhage
Humans
Incidence
Infant
Infant, Low Birth Weight
Infant, Newborn
Leukomalacia, Periventricular
Ligation
Magnesium
Magnesium Sulfate
Prognosis
Retrospective Studies
Diterpenes
Magnesium
Magnesium Sulfate
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