Diabetes Metab J.  2013 Apr;37(2):91-105. 10.4093/dmj.2013.37.2.91.

Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells

Affiliations
  • 1Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. yyoon5@emory.edu

Abstract

Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterized by reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic factors. Previous studies have tried to introduce neurotrophic or angiogenic factors in the form of protein or gene for therapy, but the effect was not significant. Recent studies have shown that bone marrow (BM)-derived stem or progenitor cells have favorable effects on the repair of cardiovascular diseases. Since these BM-derived stem or progenitor cells contain various angiogenic and neurotrophic factors, these cells have been attempted for treating experimental DN, and turned out to be effective for reversing various manifestations of experimental DN. These evidences suggest that cell therapy, affecting both vascular and neural components, can represent a novel therapeutic option for treatment of clinical DN.

Keyword

Diabetic neuropathies; Stem cells; Tissue therapy

MeSH Terms

Adult
Amputation
Angiogenesis Inducing Agents
Bone Marrow
Cardiovascular Diseases
Diabetic Neuropathies
Extremities
Foot Ulcer
Glucose
Humans
Nerve Growth Factors
Pain Management
Peripheral Nerves
Stem Cells
Tissue Therapy
Angiogenesis Inducing Agents
Glucose
Nerve Growth Factors
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