Clin Psychopharmacol Neurosci.  2014 Dec;12(3):218-221. 10.9758/cpn.2014.12.3.218.

Two-channel Near-infrared Spectroscopic Analysis of Association of Paranoia Symptoms with Prefrontal Activation

  • 1Department of Occupational Therapy, School of Health Science and Social Welfare, Kibi International University, Okayama, Japan.


The relationship between paranoia symptoms and underlying prefrontal cortex mechanisms among healthy subjects was analyzed using near-infrared spectroscopy.
Seventy-eight healthy subjects were assessed for paranoia symptoms using the Japanese version of the Paranoia Checklist. Changes in hemoglobin concentrations were assessed using 2-channel near-infrared spectroscopy on the surface of the prefrontal cortex while subjects performed a verbal fluency test.
Changes in the concentration of oxygenated hemoglobin in the prefrontal cortex during a verbal fluency test did not correlate with the Japanese version of the Paranoia Checklist.
Our findings show that the symptoms of paranoia do not negatively affect the prefrontal cortex function among healthy subjects.


Paranoia disorders; Prefrontal cortex; Near-infrared spectroscopy
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