Korean J Pediatr Infect Dis.  2014 Dec;21(3):207-213. 10.14776/kjpid.2014.21.3.207.

Association between Respiratory Virus Infection and Pneumococcal Colonization in Children

• Lee HS
• Choe YJ
• Cho EY
• Lee H
• Choi EH
• Lee HJ

• KMID: 2279094
• DOI: http://doi.org/10.14776/kjpid.2014.21.3.207

Abstract

PURPOSE
This study aimed to investigate the association between respiratory virus infection and pneumococcal colonization in children.
METHODS
From May 2009 to June 2010, nasopharyngeal (NP) aspirates were obtained from patients under 18 years old who visited Seoul National University Children's Hospital for respiratory symptoms. NP samples were used to detect respiratory viruses (influenza virus A and B, parainfluenza virus 1, 2 and 3, respiratory syncytial virus A and B, adenovirus, rhinovirus A/B, human metapneumovirus, human coronavirus 229E/NL63 and OC43/HKU1) by RT-PCR and pneumococcus by culture.
RESULTS
Median age of the patients was 27 months old. A total of 1,367 NP aspirates were tested for respiratory viruses and pneumococcus. Pneumococcus was isolated from 228 (16.7%) of samples and respiratory viruses were detected from 731 (53.5%). Common viruses were rhinovirus (18.4%), respiratory syncytial virus (RSV) A (10.6%), adenovirus (6.9%), influenza virus A (6.8%). Pneumococcal isolation rate was significantly higher in the cases of positive virus detection than negative detection [21.3% (156/731) vs. 11.3% (72/636), P<0.001]. For individual viruses, pneumococcal isolation rate was positively associated with detection of influenza virus A [24.7% (23/93) vs 16.1% (205/1274), P=0.001], RSV A [28.3% (41/145) vs 15.3% (187/1222), P=0.001], RSV B [31.3% (10/32) vs 16.3% (218/1335), P=0.042], rhinovirus A/B [22.6% (57/252) vs 15.3% (171/1115), P=0.010].
CONCLUSION
The study revealed that pneumococcal isolation from NP aspirates is related with respiratory virus detection. The result of this study could be used to investigate how respiratory viruses and pneumococcus cause clinical diseases.

Keyword

Respiratory virus; Streptococcus pneumoniae; Colonization

MeSH Terms

Adenoviridae
Child*
Colon*
Coronavirus
Humans
Metapneumovirus
Orthomyxoviridae
Paramyxoviridae Infections
Respiratory Syncytial Viruses
Rhinovirus
Seoul
Streptococcus pneumoniae

Reference

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