Korean J Pediatr Infect Dis.  2014 Dec;21(3):174-180. 10.14776/kjpid.2014.21.3.174.

Clinical and Epidemiological Study of 1,165 Hospitalized Cases of Rotaviral Gastroenteritis Before and After the Introduction of Rotavirus Vaccine, 2006-2013

• Sohn TY
• Lee CJ
• Kim YJ
• Kang MJ
• Kim SH
• Lee SY
• Lee DH
• Lee HR
• Kim KN

• KMID: 2279087
• DOI: http://doi.org/10.14776/kjpid.2014.21.3.174

Abstract

PURPOSE
This study was performed to assess the clinical and epidemiological changes after the introduction of the rotavirus vaccine in Korea, as well as to determine the efficacy of the rotavirus vaccine among hospitalized rotaviral gastroenteritis patients over the past two years.
METHODS
We analyzed yearly and seasonal patterns of 1,165 inpatients who were hospitalized for rotaviral gastroenteritis under the age of 5 years between 2006 and 2013. We also conducted a survey among 460 gastroenteritis patients who were hospitalized between 2012 and 2013 regarding the rotavirus vaccination and the symptoms of gastroenteritis. Among those individuals surveyed, clinical indices were analyzed for 124 patients who were tested positive for the rotavirus antigen.
RESULTS
The incidence of Rotaviral gastroenteritis have decreased significantly by year 2010. After the introduction and widespread dissemination of the rotavirus vaccine, the onset of the disease and the seasonal peak have been delayed. Overall, the vaccinated group showed a lower rate of positivity than the unvaccinated group. Among the hospitalized rotaviral gastroenteritis patients, the vaccinated group had a shorter hospitalization period, less severe clinical symptoms of gastroenteritis, and better laboratory test results.
CONCLUSIONS
After introduction of the rotavirus vaccine in Korea, there were two main trends observed: 1) the overall level of disease incidence was reduced; 2) the severity of rotaviral gastroenteritis cases also decreased. Based on this data, more children should receive vaccination in order to prevent the rotavirus infection and decrease the severity of rotaviral gastroenteritis.

Keyword

Rotavirus; Gastroenteritis; Vaccine; Epidemiology

MeSH Terms

Child
Epidemiologic Studies*
Epidemiology
Gastroenteritis*
Hospitalization
Humans
Incidence
Inpatients
Korea
Rotavirus Infections
Rotavirus*
Seasons
Vaccination

Figure

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  Fig. 1. Annual percentage of rotaviral gastroenteritis patients out of all gastro-enteritis patients (2006–2013).

• 

  Fig. 2. Monthly incidence rate of rotaviral gastroenteritis:(A) 2006–2009, (B) 2010–2013.

Reference

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