Korean J Pediatr Infect Dis.  2009 Dec;16(2):183-190.

Investigation on the Frequency and Severity of Common Adverse Reactions of Japanese Encephalitis Vaccines

• Kim BY
• Kim DH
• Lee HJ
• Jung SK
• Li XS
• Go UY
• Park SK
• Hong YJ

Abstract

PURPOSE
To evaluate the number and severity of adverse reactions after Japanese Encephalitis (JE) vaccination in children using different vaccines (inactivated vaccine or live attenuated vaccine) and to determine the ability and safety of the vaccines to provide effective immunization for JE.
METHODS
From August 2006 to February 2007, we conducted a prospective cohort study of the adverse reactions associated with JE immunization in Korea. We investigated common adverse reactions during the 4 days following immunization using telephone collaborations with four public health centers and nine pediatric clinics.
RESULTS
The mean age of children receiving the inactivated vaccines and live attenuated vaccines, respectively, were 1.4 y (range: 1 to 8.5) and 1.7 y (range: 1 to 8.3). The number of children that received the inactivated vaccines was 425 (64.6%). A total of 233 (35.4%) received the live attenuated vaccines. Fourteen children (3.3%) had more than one localized adverse event with the inactivated vaccine, and six (2.6%) had more than one event with the live attenuated vaccine (P=0.607). Systemic adverse reactions occurred in 5.2% vs. 8.2%, respectively, of these groups (P=0.131). Fever was more common in the live attenuated vaccine group than in the inactivated vaccine group on the day of vaccination (P=0.026).
CONCLUSIONS
The rate of adverse events in our study was even lower than that previously reported. No significant difference in outcomes between inactivated vaccine and live attenuated vaccine was found in JE-immunized children. Fever was more common in the live attenuated vaccine group than in the inactivated vaccine group on the day of vaccination.

Keyword

Japanese encephalitis; Vaccine; Adverse effects

MeSH Terms

Asian Continental Ancestry Group
Child
Cohort Studies
Cooperative Behavior
Encephalitis, Japanese
Fever
Humans
Immunization
Japanese Encephalitis Vaccines
Korea
Prospective Studies
Public Health
Telephone
Vaccination
Vaccines
Vaccines, Attenuated
Vaccines, Inactivated
Japanese Encephalitis Vaccines
Vaccines
Vaccines, Attenuated
Vaccines, Inactivated