Korean J Pediatr.  2005 May;48(5):518-522.

The Efficacy of Nebulized 3 Percent Hypertonic Saline Solution and Fenoterol in Infants with Bronchiolitis

Affiliations
  • 1Department of Pediatrics, Il Sin Christian Hospital, Busan, Korea. sss@ilsin.or.kr

Abstract

PURPOSE
To evaluate the effect of inhaled hypertonic saline solution in hospitalized infants with bronchiolitis.
METHODS
A randomized double blind trial was performed from October 2003 to May 2004. A total of eighty patients <1 year of age with a clinical diagnosis of acute viral bronchiolitis were enrolled and assigned to receive either of the following:inhalation of 2 mL(0.5 mg) fenoterol added to 2 mL of 0.9 percent saline solution(group 1; n=40) or 2 mL(0.5 mg) fenoterol added to 2 mL of 3 percent saline solution(group 2; n=40). This therapy was repeated at six hours interval after admission. They were evaluated daily just before and 20 minutes after nebulization. The outcome measures included changes in clinical severity score(based on respiratory rate, presence of wheezing, retraction, and general condition) after nebulization and duration of hospitalization.
RESULTS
In the clinical severity score, a significant improvement was observed during the 72 hours of hospitalization in both groups(P<0.05). The basic clinical severity scores before inhalation were decreased significantly faster in group 2 as compared to group 1 on each day of treatment(P<0.05). The mean duration of hospital stay was significantly reduced in group 2 than group 1(5.9+/-1.9 days versus 7.4+/-2.0 days, P<0.05). No adverse effects were associated with inhaled therapy.
CONCLUSION
These results suggest that a nebulized 3 percent saline solution plus 0.5 mg fenoterol may be more effective than a 0.9 percent saline solution plus 0.5 mg fenoterol in accelerating the clinical recovery of infants with viral bronchiolitis.

Keyword

Bronchiolitis; Hypertonic saline solution; Fenoterol

MeSH Terms

Bronchiolitis*
Bronchiolitis, Viral
Diagnosis
Fenoterol*
Hospitalization
Humans
Infant*
Inhalation
Length of Stay
Outcome Assessment (Health Care)
Respiratory Rate
Respiratory Sounds
Saline Solution, Hypertonic*
Sodium Chloride
Fenoterol
Saline Solution, Hypertonic
Sodium Chloride
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