Clin Exp Otorhinolaryngol.  2010 Sep;3(3):172-175.

Benign Pleomorphic Adenoma of the Soft Palate Metastasizing to the Sphenoid Sinus

Affiliations
  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Yeungnam University College of Medicine, Daegu, Korea. ssykhs@med.yu.ac.kr

Abstract

A benign pleomorphic adenoma is the most common tumor of the salivary glands. This tumor has the potential to metastasize to bone, the head and neck region, visceral organs and skin. Although there a few reports about a benign pleomorphic adenoma metastasizing to the maxillary sinus in the paranasal sinuses, there are no reports about a metastatic benign pleomorphic adenoma in the sphenoid sinus. We report here on a case of a benign pleomorphic adenoma of the soft palate that metastasized to the sphenoid sinus, and we briefly review the relevant clinical literature.

Keyword

Sphenoid sinus; Pleomorphic adenoma; Metastasis

MeSH Terms

Adenoma, Pleomorphic
Head
Maxillary Sinus
Neck
Neoplasm Metastasis
Palate, Soft
Paranasal Sinuses
Salivary Glands
Skin
Sphenoid Sinus

Figure

  • Fig. 1 The axial (A and B) views of the computed tomographic scan before the initial surgery show a round shaped, 4×4 cm sized mass with inhomogeneous low density (arrow) in the soft palate and no mass lesion in the sphenoid sinus. The coronal (C) and axial (D) T2-weighted magnetic resonance imaging sequences at one year after the initial surgery show a round shaped, 1×1 cm sized mass with high signal intensity (arrowhead) at the soft palate and a large mass lesion with high signal intensity (arrow) at the sphenoid sinus that apparently extends to both posterior ethmoid sinuses.

  • Fig. 2 Pathological findings of the mass show abundant myxoid and chondroid stroma with an interspersed island of epithelial cells. There are no atypical mitoses and cellular pleomorphisms. (A) The soft palate at the initial surgery (H&E, ×200). (B) The sphenoid sinus at one year after the initial surgery (H&E, ×200).


Reference

1. Lomeo P, Finneman J. Pleomorphic adenoma of the soft palate. Otolaryngol Head Neck Surg. 2001; 7. 125(1):122. PMID: 11458234.
Article
2. Nouraei SA, Ferguson MS, Clarke PM, Sandison A, Sandhu GS, Michaels L, et al. Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg. 2006; 7. 132(7):788–793. PMID: 16847191.
Article
3. Marioni G, Marino F, Stramare R, Marchese-Ragona R, Staffieri A. Benign metastasizing pleomorphic adenoma of the parotid gland: a clinicopathologic puzzle. Head Neck. 2003; 12. 25(12):1071–1076. PMID: 14648866.
Article
4. Bradley PJ. 'Metastasizing pleomorphic salivary adenoma' should now be considered a low-grade malignancy with a lethal potential. Curr Opin Otolaryngol Head Neck Surg. 2005; 4. 13(2):123–126. PMID: 15761289.
Article
5. Sabesan T, Ramchandani PL, Hussein K. Metastasising pleomorphic adenoma of the parotid gland. Br J Oral Maxillofac Surg. 2007; 1. 45(1):65–67. PMID: 15939513.
Article
Full Text Links
  • CEO
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr