Korean J Pediatr.  2006 May;49(5):545-551. 10.3345/kjp.2006.49.5.545.

Polymorphisms of the CTLA-4 promoter(-318) and exon 1(+49) genes with atopic dermatitis in Korean children

Affiliations
  • 1Department of Pediatrics and Institute of Allergy, BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. mhsohn@yumc.yonsei.ac.kr

Abstract

PURPOSE: The gene-encoding cytotoxic T lymphocyte-associated antigen-4(CTLA-4) is one of the candidate genes for conferring susceptibility to atopic dermatitis(AD). The aim of the study was to investigate the association between Korean children with AD and the polymorphisms of CTLA-4 gene promoter(-318) and exon 1(+49).
METHODS
The CTLA-4 promoter(-318 T/C) and exon 1(+49 A/G) polymorphisms were genotyped via restriction fragment length polymorphism methods in 145 children with atopic eczema, 69 children with non-atopic eczema, and 96 healthy controls.
RESULTS
There was no significant difference in genotype and allele frequencies of the CTLA-4 promoter -318 T/C and exon 1 +49 A/G polymorphisms when the atopic eczema, non-atopic eczema, and control groups were compared. Additionally the CTLA-4 promoter -318 T/C and exon 1 +49 A/G polymorphisms were not shown to be associated with severity, IgE level, or eosinophil counts.
CONCLUSION
Our data show that the polymorphisms within the CTLA-4 promoter(-318 T/C) and exon 1(+49 A/G) genes are not associated with susceptibility to AD in Korean children.

Keyword

Atopic dermatitis; CTLA-4; Polymorphism

MeSH Terms

Child*
Dermatitis, Atopic*
Eczema
Eosinophils
Exons*
Gene Frequency
Genotype
Humans
Immunoglobulin E
Polymorphism, Restriction Fragment Length
Immunoglobulin E
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