Korean J Pediatr.  2007 Jun;50(6):570-575. 10.3345/kjp.2007.50.6.570.

Polymorphism in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene in Kawasaki disease

• Han MY

• KMID: 2278489
• DOI: http://doi.org/10.3345/kjp.2007.50.6.570

Abstract

PURPOSE: To demonstrate genetic background of pathogenesis of Kawasaki disease (KD), I examined the genetic polymorphism of plasminogen activator inhibitor-1 (PAI-1) in KD patients.
METHODS
PCR-RFLP of PAI- 1 promotor gene was analyzed in 56 KD patients admitted to Kyunghee University Hospital, Gachon Medical School Gil Hospital, and Eulji Hospital from March to August 2000 and 206 normal control populations.
RESULTS
There were no differences in the genotype and allelic frequency of the PAI-1-675 (4G/5G) and PAI-1-844 (G/A) polymorphic site (which are located in the promoter region) between KD and control subjects. Also I could not detect any significant differences in specific genotypes between patients with the coronary artery lesion (CAL) and patients without CAL.
CONCLUSION
No association was observed in -844 G/A and -675 4G/5G of PAI-1 gene polymorphism with KD.

Keyword

Kawasaki disease; Genetic Polymorphsm; Plasminogen activator inhibitor

MeSH Terms

Coronary Vessels
Genotype
Humans
Mucocutaneous Lymph Node Syndrome*
Plasminogen Activator Inhibitor 1
Plasminogen Activators*
Plasminogen*
Polymorphism, Genetic
Promoter Regions, Genetic*
Schools, Medical
Plasminogen
Plasminogen Activator Inhibitor 1
Plasminogen Activators