Clin Exp Otorhinolaryngol.  2014 Jun;7(2):145-148.

Sinonasal Glomangiopericytoma Causing Oncogenic Osteomalacia

• Lee GG
• Dhong HJ
• Park YS
• Ko YH

Abstract

A 60-year-old woman suffered from recurrent femur neck fracture. Laboratory data showed serum hypophosphatemia, elevated alkaline phosphatase, normal serum calcium levels, and normal parathyroid hormone levels. Radiological examinations revealed a tumor in the right maxillary alveolar bone. The nasal cavity mass was removed, and the histological features were those of glomangiopericytoma. After removal of the tumor, some of the laboratory data normalized. Based on the clinical features, histopathological diagnosis and postoperative course of events, a diagnosis of glomangiopericytoma causing oncogenic osteomalacia was confirmed. We report a case of oncogenic osteomalacia caused by sinonasal glomangiopericytoma.

Keyword

Hemangiopericytoma; Oncogenous osteomalacia

MeSH Terms

Alkaline Phosphatase
Calcium
Diagnosis
Female
Femoral Neck Fractures
Hemangiopericytoma
Humans
Hypophosphatemia
Middle Aged
Nasal Cavity
Osteomalacia*
Parathyroid Hormone
Alkaline Phosphatase
Calcium
Parathyroid Hormone

Figure

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  Fig. 1 Preoperative computed tomography. Coronal (left) and axial (right) enhancing computed tomography scans showing a residual tumor with mild heterogeneous enhancement in the right maxillary sinus posterior wall (arrows).

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  Fig. 2 Pathologic findings. H&E staining (×180) revealed numerous thin-walled, branching staghorn vessels surrounded by oval to spindle-shaped cells (A). Immunohistochemical staining showed a negative reaction to CD31 (B), a negative reaction to CD34 (C), and a positive reaction to smooth muscle actin (D). (B-D) Immunohistochemistry, ×250.

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  Fig. 3 Postoperative seven months endoscope finding of right maxillary sinus through inferior meatal antrostomy. There is no evidence of residual or recurrent tumor.

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