Korean J Otorhinolaryngol-Head Neck Surg.  2008 Sep;51(9):790-795.

Clinical Review of Inverted Papilloma and Oncocytic Schneiderian Papilloma

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hysiam.kim@samsung.com


BACKGROUND AND OBJECTIVES: Oncocytic schneiderian papilloma (OSP) is uncommon benign sinonasal neoplasm that arise from the sinonasal epithelium. Because of its rare incidence, OSP is not well-known by clinicians and report of this disease is uncommon. The aim of this study was to review the pathological features and variations of sinonsasl papillomas and to compare clinical behaviors of Inverted papiloma (IP) with OSP. SUBJECTS AND METHOD: A retrospective review and pathological assessment were performed on 99 sinonasal papilloma patients. Parameters for comparison included the origin site, radiologic finding, recurrence and malignancy rates. Predictive factors for recurrence and malignancy included histological variations of IP versus OSP.
Eighty-eight patients (88%) were diagnosed with inverted papilloma and 11 patients (11%) were OSP. Recurrence developed in one patient with OSP (9%) and six patients with IP (7%). Six cases (7%) of carcinoma ex papilloma were seen only in IP. OSP was more often presented as a mixed form with inverted papilloma, rather than in the pure form. The histological variations and radiological findings, regardless of its difference, did not statistically impact recurrence rate and malignant transformation rate.
The common mixed features of OPS and IP explains that these two lesions have the common etiological factor. In our study, there are no significant differentiations in clinical manifestation and prognosis. A larger number of cases for analysis would be necessary to confirm the properties of OSP.


Inverted papilloma; Papilloma; Neoplasm; Sinonasal
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